Site of action of 1-methyladenine in inducing oocyte maturation in starfish

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Abstract

The site of action of 1-methyladenine, which has been identified as a natural inducer of oocyte maturation in starfishes, was investigated by comparing the effect of this substance when injected into the oocytes with the effect following external application. The microinjection of 1-methyladenine (10−13 mole) into the inside of an oocyte failed to induce the breakdown of the germinal vesicle, whereas the external application of this substance (3.3 × 10−7 M in concentration, 10−14 mole/oocyte in total amount) invariably brought about oocyte maturation. These results indicate that this substance acts on the surface of the oocyte from the outside.

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This work has been supported in part by a grant-in-aid from the Ministry of Education.

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