Steroidogenic activities of two distinct salmon gonadotropins

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Abstract

The effects of salmon gonadotropins, GTH I and GTH II, on production of two major steroid hormones in female salmonid reproduction, estradiol-17β and 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-diOHprog) were compared using amago salmon (Oncorhynchus rhodurus) intact ovarian follicles in vitro. In addition, the production of 17α-hydroxyprogesterone (17α-OHprog) by thecal layers and 17α,20β-diOHprog by granulosa layers in response to GTH I and II was examined during oocyte maturation. Both GTHs enhanced estradiol-17β production by midvitellogenic ovarian follicles in a dose-dependent manner; there was no significant difference in potency between GTH I and II. In postvitellogenic follicles, GTH II appeared to be more effective in stimulating 17α,20β-diOHprog production than GTH I. GTH II was also found to be more potent than GTH I in stimulatin 17α-OHprog production by thecal layers and 17α,20β-diOHprog production by granulosa layers in the presence of 17α-OHprog. Thus, GTH II appears to differ from GTH I showing a reproductively high specificity for 17α,20β-diOHprog production during oocyte maturation.

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