Elsevier

Vision Research

Volume 23, Issue 12, 1983, Pages 1501-1510
Vision Research

Behavioral studies on the effect of abnormal early visual experience in monkeys: Spatial modulation sensitivity

https://doi.org/10.1016/0042-6989(83)90162-1Get rights and content

Abstract

Spatial modulation sensitivity functions have been investigated by behavioral methods in two monkeys reared with normal visual experience and 12 monkeys reared with abnormal, early visual experience. Experimental treatments were initiated when the animals were approximately one month of age. Two monkeys were each treated with one of the following procedures:

  • (1) long-term monocular lid suture.

  • (2) short-term monocular lid suture.

  • (3) surgically induced esotropia.

  • (4) surgically induced exotropia.

  • (5) optical dissociation of binocular vision with ophthalmic prisms

  • (6) chronic monocular cycloplegia.

The results of the studies showed a severe loss of contrast sensitivity of the treated eyes compared to the control eyes for monkeys reared with monocular lid suture or surgically induced esotropia. Surgically induced exotropia resulted in a moderate reduction in sensitivity of the deviated eye while optical dissociation resulted in a mild reduction in sensitivity of one eye compared to the other. One of the two monkeys reared for seven months with chronic monocular cyclopegia had a relative reduction in contrast sensitivity of the treated eye, but the other monkey had equal sensitivities in the two eyes. However, binocular summation experiments showed that even though the relative difference between the monocular sensitivities was small or absent for the monkeys reared with optical dissociation or chronic monocular cycloplegia, none of them demonstrated binocular vision in these experiments.

Reference (41)

  • SmithE.L. et al.

    Effects of chronic atropinization on visual acuity in kittens

    Behav. Brain Res.

    (1983)
  • WilliamsR.A. et al.

    Oblique effects in normally reared monkeys (Macaca nemestrina): Meridional variations in contrast sensitivity measured with ope´rant techniques

    Vision Res.

    (1981)
  • BlakeR. et al.

    Spatial properties of binocular neurones in the human visual system

    Expl Brain Res.

    (1977)
  • BlakemoreC. et al.

    The physiological effects of monocular deprivation and their reversal in the monkey's visual cortex

    J. Physiol., Lond.

    (1978)
  • BlakemoreC. et al.

    Recovery from monocular deprivation in the monkey. 1. Reversal of physiological effects in the visual cortex

  • BootheR.G. et al.

    Anisometropic amblyopia inMacaca nemestrina monkeys produced by atropinization of one eye during development

    Invest. Ophthal. visual Sci.

    (1982)
  • CampbellF.W. et al.

    Optical and retinal factors affecting visual resolution

    J. Physiol., Lond.

    (1965)
  • CampbellF.W. et al.

    Monocular versus binocular visual acuity

    Nature

    (1965)
  • CampbellF.W. et al.

    Optical quality of the human eye

    J. Physiol., Lond.

    (1966)
  • CrawfordM.L.J. et al.

    Concomitant strabismus and cortical eye dominance in young rhesus monkeys

    Trans. Ophlhal. Soc. U.K.

    (1979)
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    Supported by Research grants EY 01139, EY 03611 and EY 01120 from the National Eye Institute.

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