Cell
Volume 64, Issue 1, 11 January 1991, Pages 91-97
Journal home page for Cell

Article
Identification of an autocrine negative growth factor: Mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator

https://doi.org/10.1016/0092-8674(91)90211-GGet rights and content

Abstract

Murine β-galactoside-binding protein, a protein classified as a soluble lectin, is shown to be a cell growth-regulatory molecule and a cytoatatic factor. The growth-inhibitory effect is not related to lectin properties, and competition assays indicate that the protein binds to specific cell surface receptors with high affinity. It exerts control in G0 and at G2, both as a regulator of cell replication and as a cytostatic factor.

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