Cell
Volume 79, Issue 6, 16 December 1994, Pages 971-980
The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily
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A single chemosensory GPCR is required for a concentration-dependent behavioral switching in C. elegans
2022, Current BiologyCitation Excerpt :Two pairs of amphid chemosensory neurons, AWC and AWA, are required for chemotaxis to most, if not all, volatile odors.5 To determine which chemosensory neurons mediate attraction to these compounds, we first examined chemotaxis to these compounds in the AWC-defective ceh-36 OTX transcription factor mutant and the AWA-defective odr-7 nuclear receptor mutant.14,15 We found that ceh-36 mutants exhibited little or no attraction to all three compounds, whereas odr-7 mutants showed normal or even increased chemotaxis to them (Figures 1F–1H).
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