Low threshold calcium spikes, intrinsic neuronal oscillation and rhythm generation in the CNS
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Cited by (35)
The role of plasticity in the recovery of consciousness
2022, Handbook of Clinical NeurologyCitation Excerpt :Intracellular recordings from the thalamic reticular nucleus and thalamocortical projections highlight a critical common feature for both electroencephalographic rhythm modulation and thalamocortical plasticity: the rhythmic occurrence of action potential bursts driven by voltage-dependent Ca2 + spikes (Hughes et al., 2002; Crunelli et al., 2018). The rhythmic activities that occur with the sleep spindles, delta waves, and slow waves of NREM sleep have an intraspike frequency of 100–500 Hz and are known as low-threshold spikes (LTSs) (Gutnick and Yarom, 1989). LTSs are different from the activities found during alpha waves of relaxed wakefulness and the theta waves of light NREM sleep, when action potential bursts in thalamocortical neurons have a lower frequency (50–70 Hz) and are driven by high-threshold Ca2 + spikes.
Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Among these, ‘T-type calcium channels’ refer to transient or low-voltage-activated channels. T-type calcium channels are reported to be strongly associated with the generation of rhythmic firing patterns in the CNS (Llinás and Yarom, 1981; Gutnick and Yarom, 1989), raising the possibility that blockers of these channels may have therapeutic potential for tremors. It was recently reported that T-type calcium channel blockers exhibited anti-tremor effects on harmaline-induced tremor, an experimental model of essential tremor (Yang et al., 2008; Handforth et al., 2010).
Morphological and electrophysiological characteristics of neurons within identified subnuclei of the lateral habenula in rat brain slices
2011, NeuroscienceCitation Excerpt :Corresponding electrophysiological behavior was previously reported in LHb neurons of guinea pigs (Wilcox et al., 1988). Burst firing in individual LHb neurons has been supposed to underlay synchronized network activity (Gutnick and Yarom, 1989). A salient electrophysiological feature of LHb projection neurons is their high membrane input resistance (Rm), regardless of morphological and physiological categories.
Morpholin-2-one derivatives as novel selective T-type Ca<sup>2+</sup> channel blockers
2006, Bioorganic and Medicinal Chemistry LettersSynthesis and SAR studies of a novel series of T-type calcium channel blockers
2006, Bioorganic and Medicinal Chemistry