Symposium paperShape space: an approach to the evaluation of cross-reactivity effects, stability and controllability in the immune system
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2010, Physica A: Statistical Mechanics and its ApplicationsCitation Excerpt :Before doing so, we now briefly summarize the model. In this way, as often done in modern modeling of antibody affinities [10,11], we relax the earlier simplifying assumption of “a perfect mirror of a mirror” for the interacting Ig simply assuming that the better the matches among idiotopes and the stronger the stimulus occurring between the respective clones via their immunoglobulins. Roughly speaking, recalling the previous example, both the strings (1001000), (1001001) are reactive with (0110110), but for the second the interaction is stronger as it matches all the entries.
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