Research paperHyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system
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2022, iScienceCitation Excerpt :First, we presumed dysregulation of dopaminergic system as a basis of hyperactivity because experimental manipulation of the rodent dopaminergic system is known to induce hyperactive states and dopamine system genes are associated with hyperactivity in ADHD (Gallo and Posner, 2016; Koob et al., 1981). However, our monoamine analysis revealed no change in dopamine or its metabolites in the nucleus accumbens, which is critical for hyperactivity caused by dopaminergic dysregulation (Koob et al., 1981). In addition, methylphenidate did not rescue the hyperactivity phenotype.
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2019, Physiology and BehaviorCitation Excerpt :Doses that produce primarily locomotor-activating effects tend to be more rewarding, whereas doses that result in stereotypy tend to be more aversive in rats [12–15]. Locomotor-activating effects are mediated primarily by dopaminergic mesolimbic projections to the ventral striatum, and stereotypy effects are mediated primarily by dopaminergic nigrostriatal projections to the dorsal striatum [9,16–18]. Further, lower doses are often better able to detect group differences than are higher doses, perhaps related to ceiling effects [15,19,20].
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