Psychobiology of novelty seeking and drug seeking behavior

doi:10.1016/0166-4328(95)00203-0

Behavioural Brain Research

Volume 77, Issues 1–2, May 1996, Pages 23-43

https://doi.org/10.1016/0166-4328(95)00203-0 Get rights and content

Abstract

There is considerable evidence that high novelty seekers are at increased risk for using drugs of abuse relative to low novelty seekers. This review examines the potential biological mechanism that may help explain the relationship between novelty seeking and drug seeking behavior. Evidence is summarized to suggest that exposure to novelty activates, at least in part, the same neural substrate that mediates the rewarding effects of drugs of abuse. It is argued that individual differences in response to novelty and drugs may relate to individual differences in the mesolimbic dopamine (DA) system of the brain. Individual differences in both novelty seeking and drug seeking behavior, while under some degree of genetic control, appear to be modifiable by early developmental experiences and this modification may relate to alterations in activity of the mesolimbic DA system. Within the context of this biological formulation, implications for the prevention and treatment of drug abuse are discussed.

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Psychobiology of novelty seeking and drug seeking behavior

Abstract

Neuroscience

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Neuropharmacology

Brain Res.

Pharmacol. Biochem. Behav.

Life Sci.

Pharmacol. Biochem. Behav.

Neuroscience

Neuroscience

Int. J. Psychophysiol.

Neurosci. Biobehav. Rev.

Pers. Ind. Diff

Behav. Brain Res.

Physiol. Behav.

Brain Res.

Brain Res.

Pharmacol. Biochem. Behav.

Behav. Brain Res.

J. Exp. Child. Psychol.

Neurosci. Lett.

Psychiat. Res.

J. Res. Pers.

Alcohol

Pharmacol. Biochem. Behav.

Addict. Behav.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Brain Res.

Pharmacol. Biochem. Behav.

Neuroscience

Anim. Behav.

Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens and medial frontal cortex

J. Neurochem.

Exploring the connections between platelet monoamine oxidase activity and behavior

Neuropsychobiology

Opiate addiction: the case for an adaptive orientation

Psychol. Bull.

The relationship of MMPI and sensation seeking scales to adolescent drug use

J. Pers. Assess.

Neurotransmitter systems and personality measurements: a study in psychosomatic patients and healthy subjects

Neuropsychobiology

Thyroid hormone correlates of sensation seeking and anxiety in healthy human females

Neuropsychobiology

Gonadal hormone correlates of sensation seeking and anxiety in healthy human females

Neuropsychobiology

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats

J. Pharmacol. Exp. Ther.

Role of dopamine D1 and D2 receptors in novelty-maintained place preference

Exp. Clin. Psychopharmacol.

The effect of sensation seeking needs on alcohol and marijuana use in adolescence

Bull. Soc. Psychol. Addict. Behav.

The arousal and satiation of perceptual curiosity in the rat

J. Comp. Physiol. Psychol.

Genes, environment and personality

Science

Discrimination learning by rhesus monkeys to visual-exploration motivation

J. Comp. Physiol. Psychol.

Discrimination learning by rhesus monkeys to auditory incentives

J. Comp. Physiol. Psychol.

The effect of deprivation of visual incentives on visual exploration motivation in monkeys

J. Comp. Physiol. Psychol.

Modulation of cocaine selfadministration in the rat through D-3 dopamine receptors

Science

Establishment of chronic intravenous drug self- adminstration in the C57BL/6J mouse

NeuroReport

Role of dopamine D₁ and D₂ receptors in novelty-maintained place preference