Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum
References (23)
- et al.
Isolation of a Plasmodium falciparum rhoptry antigen
Mol. Biochem. Parasitol.
(1985) - et al.
A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodies
Mol. Biochem. Parasitol.
(1986) - et al.
In vivo time course of synthesis and processing of major schizont membrane polypeptides in Plasmodium falciparum
Mol. Biochem. Parasitol.
(1986) - et al.
A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum
Mol. Biochem. Parasitol.
(1985) - et al.
Early events in the biosynthesis of the lysosomal enzyme cathepsin D
J. Biol. Chem.
(1979) - et al.
Localization, biosynthesis, processing and isolation of a major 126 kDa antigen of the parasitophorous vacuole of Plasmodium falciparum
Mol. Biochem. Parasitol.
(1987) - et al.
Protective monoclonal antibodies recognizing stage specific merozoite antigens of a rodent malarial parasite
Nature
(1980) - et al.
Immunization against blood stage rodent malaria using purified parasite antigens
Nature
(1981) - et al.
Ultrastructural localization of protective antigens of Plasmodium yoelii merozoites by the use of monoclonal antibodies and ultrathin cryomicrotomy
Am. J. Trop. Med. Hyg.
(1984) - et al.
Immunity to asexual erythrocytic stages of Plasmodium falciparum
Monoclonal antibody characterization of Plasmodium falciparum antigens
Am. J. Trop. Med. Hyg.
Cited by (64)
Toxoplasma secretory proteins and their roles in parasite cell cycle and infection
2020, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and MethodsSecretory organelle trafficking in Toxoplasma gondii: A long story for a short travel
2018, International Journal of Medical MicrobiologyCitation Excerpt :Electron microscopy (EM) studies revealed that pre-rhoptries resemble secretory granules and develop into mature organelles by condensation and elongation of the neck region towards the conoid of the developing daughter tachyzoites (Dubremetz, 2007). As studied in Plasmodium falciparum, where PfRON4 was found in the pre-rhoptries (Roger et al., 1988) before being transported to the mature rhoptry neck, the sub-compartmentalization between ROPs and RONs supposedly takes place via lateral protein sorting and not by fusion of distinct compartments. Finally, anchoring of the maturing rhoptries to the apical complex relies on the activity of the Armadillo Repeats Only protein, TgARO (Mueller et al., 2013).
Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility
2017, Journal of Biological ChemistryCitation Excerpt :Mouse anti-PfELC antibodies were raised by immunization of female BALB/c mice with recombinant His-tagged protein (production of which is described below). Other primary polyclonal antibodies and mAbs used were anti-PfMTIP (40), anti-PfGAP45 (18), anti-PfGAP50 (26), anti-PfRON4 mAb (57), and anti-PbP28 mAb 13.1 (58), which are described in the referenced works. Rabbit anti-GFP11 and rat anti-HA (monoclonal 3F10; Roche Applied Science) antibodies were used to detect tagged proteins.
Toxoplasma Secretory Proteins and Their Roles in Cell Invasion and Intracellular Survival
2013, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second EditionWherever i may roam: Protein and membrane trafficking in P. falciparum-infected red blood cells
2012, Molecular and Biochemical ParasitologyCitation Excerpt :In transmission electron micrographs, the neck appears electron-lucent while the bulb is electron-dense and contains internal membranes reminiscent of multivesicular endosomes in higher eukaryotes [142–144]. Individual proteins are not distributed throughout the rhoptry but are sub-compartmentalized within either the bulb or the neck [136,145,146]. Proteins that have so far been identified residing in the neck of the rhoptries are involved in irreversible attachment and tight junction formation [133,135] whereas bulb proteins are thought to be involved in the generation and establishment of the PV and RBC remodeling [147].
Dissecting the apicomplexan rhoptry neck proteins
2010, Trends in ParasitologyCitation Excerpt :A summary of the characterized apicomplexan rhoptry bulb proteins is provided in Box 2, and more extensive discussions can be found elsewhere [31,32]. A 1980 study was the first to identify a protein that localized to the rhoptry neck in Plasmodium[33]; however, more recent investigations have shown that the rhoptry neck contains a distinct set of proteins, some of which are required for host cell invasion (Box 1), either in binding to the host cell plasma membrane or in the formation of the tight junction [6–9,11,12,34–41]. The proteins that bind to the host cell plasma membrane, such as the reticulocyte binding-like (RBL) protein family, are not a primary focus of this review, and are mentioned only in Box 3.