Trends in Genetics
Volume 12, Issue 7, July 1996, Pages 258-262
Journal home page for Trends in Genetics

Review
Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins

https://doi.org/10.1016/0168-9525(96)10026-3Get rights and content

Abstract

For many DNA-binding transcription factors it is often difficult to reconcile their highly specific in vivo functions with their less specific in vitro DNA-binding properties. Cooperative DNA binding with cofactors often provides part of the answer to this paradox and recent studies have demonstrated this to be the case for the homeotic complex (HOX) family of transcription factors. However, the unique problem posed by these highly related and developmentally important transcription factors requires additional twists to the standard solution, which are beginning to become apparent from the characterization of the HOX cofactors encoded by the extradentrile and PBX genes.

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