Trends in Genetics
Volume 12, Issue 11, November 1996, Pages 467-471
Journal home page for Trends in Genetics

Review Yeast review series
Maintenance and inheritance of yeast prions

https://doi.org/10.1016/0168-9525(96)10045-7Get rights and content

Abstract

The unusual genetic behaviour of two yeast extrachromosomal elements [PSI] and [URE3] is entirely consistent with a prion-like mechanism of inheritance involving an autocatalytic alteration in the conformation of a normal cellular protein. In the case of both yeast determinants the identity of the underlying cellular prion protein is known. The discovery that the molecular chaperone Hsp104 is essential for the establishment and maintenance of the [PSI] determinant provides an explanation for several aspects of the puzzling genetic behaviour of these determinants. What remains to be explained is whether these determinants represent ‘disease states’ of yeast or represent the first examples of a unique mechanism for producing a heritable change in phenotype without an underlying change in genotype.

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