Cancer Letters

Cancer Letters

Volume 75, Issue 3, 20 December 1993, Pages 143-149
Cancer Letters

Enhanced activity of CMP-NeuAc:Galβ1-4GlcNAc:α2,6-sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients

https://doi.org/10.1016/0304-3835(93)90056-FGet rights and content

Abstract

The activity of sialyltransferases with different linkage specificities, of a Galβ1-4GlcNAc:α2,6-sialyltransferase and a Galβ1-4GlcNAc:α2,3-sialyltransferase, was studied in human colorectal tumor tissue from surgical specimens, normal mucosa, liver and liver metastases, and serum of patients suffering from colorectal carcinomas. While α2,3-specific activity was equally high in tumor and mucosa samples, the activity of the α2,6-specific enzyme was increased in tumor tissue and particularly in metastasizing tumors. Also, compared to healthy individuals, serum of patients suffering from metastasizing tumors contained a significantly higher activity of the α2,6-specific enzyme. These results demonstrate that specific sialyltransferase isoforms are expressed in metastasizing tumors and that determination of such isoforms may be a new means for tumor detection and monitoring.

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