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2016, International Review of Cell and Molecular BiologyCitation Excerpt :Tau can be posttranslationally modified by glycosylation, ubiquitination, glycation, sumoylation, polyamination, nitration, truncation, and phosphorylation, the latter being extensively studied in the field of AD (Gong et al., 2005). At physiologic conditions, tau is enriched in the axonal compartment (Kempf et al., 1996), but some tau is also present in dendrites (Dotti et al., 1987; Papasozomenos and Binder, 1987). During AD, a higher fraction of tau becomes located in the somatodendritic compartment (Brandt et al., 2005).
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2015, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Indeed, tau was localized in the soma of pyramidal cells in aged mice, and in neurofibrillary tangles in AD-affected human samples. A differential distribution of tau in neurons has been described depending on its phosphorylation state, being dephosphorylated tau located primarily in distal regions of the axon, and phosphorylated tau being present in the somatodendritic compartment [67], which is in accordance with our results. As we have shown, expression levels of non P-tau seem to be age-independent, both in mice and human control samples.