Transient period of correlated bursting activity during development of the mammalian retina

doi:10.1016/0896-6273(93)90122-8

Neuron

Volume 11, Issue 5, November 1993, Pages 923-938

https://doi.org/10.1016/0896-6273(93)90122-8 Get rights and content

Abstract

The refinement of early connections in the visual pathway requires electrical activity in the retina before the onset of vision. Using a multielectrode array, we have shown that the spontaneous activity of cells in the neonatal ferret retina is correlated by patterns of periodically generated traveling waves. Here, we examine developmental changes in the characteristics of the waves and show that retinal ganglion cells participate in these patterns of activity, which are seen during the same period as synaptic modification in the lateral geniculate nucleus; that the waves subside gradually as the connectivity in the lateral geniculate nucleus stabilizes; and that their spatial structure allows for refinement of the retinotopic map, as well as for eye-specific segregation in the lateral geniculate nucleus.

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^∗: Present address: Vision, Touch and Hearing Research Center, University of Queensland, St. Lucia, Queensland 4072, Australia.

^†: Present address: Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.

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Neuron

ArticleTransient period of correlated bursting activity during development of the mammalian retina

Abstract

Trends Neurosci.

Neuron

Exp. Eye Res.

Neuron

J. Neurosci. Meth.

Neuron

Brain Res.

Neurosci. Lett.

In vitro retina as an experimental model of the central nervous system

J. Neurochem.

Relationship between receptive and dendritic field size of amacrine cells in the rabbit retina

J. Neurophysiol.

Hebbian synapses: biophysical mechanisms and algorithms

Annu. Rev. Neurosci.

Transient synapses formed by individual retinogeniculate axons during segregation of eye input in the cat

J. Neurosci.

Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways

Annu. Rev. Neurosci.

Glutamate induces calcium waves in cultured astrocytes: long range filial signaling

Science

The development of the retinogeniculate pathways in normal and albino ferrets

A role for action-potential activity in the development of neuronal connections in the kitten retinogeniculate pathway

J. Neurosci.

Spontaneous impulse activity of rat retinal ganglion cells in prenatal life

Science

Histogenesis of the ferret retina

Exp. Eye Res.

Hippocampal longlasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents

J. Neurosci.

Mechanisms underlying long-term potentiation of synaptic transmission

Annu. Rev. Neurosci.

Correlation in the discharges of neighboring rat retinal ganglion cells during prenatal life

Article
Transient period of correlated bursting activity during development of the mammalian retina