Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information
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Fuzzy binding model of molecular interactions between tropoelastin and integrin alphaVbeta3
2021, Biophysical JournalCitation Excerpt :Moreover, the mechanisms for tropoelastin-based integrin activation remain largely unknown. It is crucial to understand the nature of the tropoelastin-integrin interaction, as the effects of cell attachment on tropoelastin have direct consequences for elastic fiber and cell organization in three-dimensional tissue architectures (15–18). Here, a computational approach was undertaken to further explore the nature of the interaction between tropoelastin and integrin αvβ3.
Targeted Drug Delivery: Advancements, Applications, and Challenges
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2019, General and Comparative EndocrinologyCitation Excerpt :MMPs are ECM degrading enzymes that are implicated in regulating cell fate and tissue remodeling in development and pathogenesis. The ECM, consisting of many proteins and other macromolecules (Hay, 1991; Timpl and Brown, 1996), provides a structural support for tissues and interacts with cells through cell surface receptors (Damsky and Werb, 1992; Schmidt et al., 1993; Brown and Yamada, 1995) as well as regulating the availability of signaling molecules (Vukicevic et al., 1992; Werb et al., 1996). ECM remodeling and degradation by MMPs can thus affect cell fate and behavior (Shi et al., 1998).
Topotaxis: A New Mechanism of Directed Cell Migration in Topographic ECM Gradients
2018, Biophysical JournalCitation Excerpt :The fibers of the matrix present the cells with structurally and chemically complex contact interfaces. Cells use a range of specialized receptors (most notably a family of integrin hetero-dimers) to attach to and be stimulated by the surrounding ECM fibers (7–10). This interaction can also lead to matrix remodeling by the cells, with the ECM fibers being deformed, re-oriented, degraded, and synthesized by the cells, particularly fibroblasts and other cells specialized for this function (11,12).
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