Current Biology
Research paperThe origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells
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Cited by (76)
Mechanisms Underlying Recurrent Genomic Amplification in Human Cancers
2020, Trends in CancerCitation Excerpt :Several models have been proposed to explain how DMs arise (Figure 3). Earlier molecular and cytogenetic studies revealed that a chromosome break triggers the deletion of a chromosomal region that becomes a circular DNA [40,103]. By contrast, glioma cells harboring EGFR DMs retain EGFR gene copies at the native chromosomal locus [47].
Telomere dysfunction and chromosome instability
2012, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCitation Excerpt :Although it is now clear that B/F/B cycles resulting from telomere loss can result in genomic instability, questions remain as to the role of B/F/B cycles in gene amplification in human cancer. B/F/B cycles were recognized long ago as a mechanism for gene amplification in rodent cells [21–23]; however, evidence was initially lacking that B/F/B cycles were associated with gene amplification in human cells. Gene amplification in rodent cells was obvious due to the breakage of the fused chromosomes far from the site of fusion, producing large “ladder-like” repeats visible by cytogenetic analysis.
Gene amplification, radiation sensitivity and DNA double-strand breaks
2010, Mutation Research - Reviews in Mutation ResearchTelomeres and chromosome instability
2006, DNA RepairExtrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications
2023, Frontiers in Oncology