Chapter 304 - Carboxypeptidase M
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Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ<inf>15-42</inf>
2019, Translational ResearchDownregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling
2015, Cellular SignallingCitation Excerpt :The kB2R is selectively activated by the peptides bradykinin (BK) or kallidin (KD; Lys-BK) cleaved from kininogen precursors by plasma or tissue kallikrein [1,2]. BK or KD is inactivated as kB2R agonists by removal of their C-terminal Arg by plasma carboxypeptidase (CP) N [3,4] or membrane CPM [5–7] but the metabolites generated, des-Arg9-BK (DABK) or des-Arg10-KD (DAKD), are instead specific agonists of the kB1R [2,8,9]. Typically, the kB2R is constitutively expressed in a variety of cell types in contrast to the kB1R whose expression is induced by injury or inflammation [1,2].
Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor
2013, Journal of Biological ChemistryCitation Excerpt :They are distinguished from the CPA/B (M14A) subfamily by the lack of a propeptide activation sequence and the presence of an additional C-terminal domain consisting of a seven-stranded β barrel with topological similarity to the plasma protein transthyretin (2, 6, 7). CPM is an ectoenzyme anchored to the plasma membrane of cells by a glycosylphosphatidylinositol (GPI) anchor (8, 9) and is widely distributed in the body, for example in lung and placental microvilli, kidney, blood vessels, intestine, brain, and peripheral nerves and can be found in soluble form in various body fluids (1, 10, 11). CPM has a strict specificity, cleaving only C-terminal Arg or Lys residues (12), and although >60 endogenous human peptides or proteins have been identified as potential CPM substrates, only 22 have been tested and shown to have altered activity after C-terminal cleavage (10).
Targeted proteomic response to coffee consumption
2020, European Journal of NutritionDrosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate
2019, European Journal of NeuroscienceInteractions between carboxypeptidase M and kinin B1 receptor in endothelial cells
2019, Inflammation Research