Chapter 3 - The Cell Biology of Neural Crest Cell Delamination and EMT
References (0)
Cited by (7)
Hox proteins as regulators of extracellular matrix interactions during neural crest migration
2022, DifferentiationCitation Excerpt :NCCs first emerge at the dorsal aspect of the neural tube along the majority of the anterior-posterior (A-P) axis of the elongating embryo in response to a mélange of signaling factors; including, WNTs, BMPs, FGFs, Retinoic Acid, and TGFβ signaling (Conlon, 1995; Goldstein et al., 2005; Hosokawa et al., 2010; Li et al., 2009). At the time of specification, NCCs can be segregated into four major subpopulations which are collinear with their axial region of origin; namely the cranial, vagal, trunk, and sacral (Bronner, 2012; Rothstein et al., 2018) Shortly after their specification, NCCs delaminate from the neural tube and assume mesenchymal character just prior to their emigration, a process known as epithelial-to-mesenchymal transition (EMT) (Taneyhill and Padmanabhan, 2014). Following delamination, NCCs migrate along stereotypic routes throughout the embryo, guided both by NCC-mesenchyme interactions and chemotaxis.
Diabetes, Oxidative Stress, and DNA Damage Modulate Cranial Neural Crest Cell Development and the Phenotype Variability of Craniofacial Disorders
2021, Frontiers in Cell and Developmental BiologyNeural crest development: insights from the zebrafish
2020, Developmental Dynamics