Neural Crest Cells

Neural Crest Cells

Evolution, Development and Disease
2014, Pages 51-72
Neural Crest Cells

Chapter 3 - The Cell Biology of Neural Crest Cell Delamination and EMT

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The epithelial-to-mesenchymal transition (EMT) plays an important role in the lifecycle of neural crest cells (NCC) by enabling detachment from their site of generation and subsequent migration to various destinations to form differentiated tissues. During this process, NCC have to drastically change their architectural landscape, which involves the loss of cell adhesion and polarity, activation of locomotory processes, and gene expression changes that directly and indirectly enable each of these features. Importantly, the cell biological changes accompanying EMT are required for the generation of motile NCC from stationary precursors. As such, the processes associated with NCC EMT must be orchestrated in a precise spatiotemporal manner in order to build a functioning organism.

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