Effect of cytochalasin B on conventional drainage of aqueous humor in the cynomolgus monkey

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The effect of intracameral infusion of cytochalasin B (25μg/ml) on gross outflow facility, true facility, uveoscleral flow, and aqueous humor formation was determined in cynomolgus monkeys. The results indicate that cytochalasin B causes a marked decrease in resistance to flow through the tissues between the anterior chamber and the canal of Schlemm. The effect was present in normal eyes and in an eye in which the ciliary muscle had been disinserted from the scleral spur.

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