Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children*

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Summary

Aspects of 5-hydroxyindole metabolism have been studied in some groups of mentally retarded children. Six of 23 children with the diagnosis of infantile autism had consistently elevated blood 5-HT levels. The mean level of blood 5-HT of other severely retarded children was higher than that of the mildly retarded group. No specific clinical signs could be found in these children.

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    • Cited by (0)

    *

    This investigation was supported in part by Traineeship NBI-EP BT-507 from the National Institute of Neurological Diseases and Blindness and by United States Public Health Service Grant M-1204, National Institute of Mental Health.

    *

    Section of Neurology, Yale University School of Medicine. Present address, National Institute for Medical Research, Mill Hill, London N. W. 7.

    **

    National Institute of Mental Health, Yale University School of Medicine. Address, Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Conn.

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    Copyright © 1961 Published by Mosby, Inc.