Elsevier

Life Sciences

Volume 62, Issue 7, 9 January 1998, Pages 687-695
Life Sciences

Oral administration of rutoside can ameliorate inflammatory bowel disease in rats

https://doi.org/10.1016/S0024-3205(97)01164-8Get rights and content

Abstract

Rutoside, a flavonoid with antioxidant properties, was tested for acute and chronic antiinflammatory activity in trinitrobenzenesulfonic acid-induced rat colitis. Pretreatment with 10 or 25 mgkg of rutoside by the oral route reduced colonic damage at 2 days. Several mechanisms can be involved in this activity, and one of these may be related to its ability in preventing glutathione depletion of colitic animals, and this could result in mucosal protection against oxidative insult. When rutoside was tested for 1 and 2 weeks after colitis induction, it was able to promote colonic healing. The chronic effect of the flavonoid was also related with its ability to increase colonic glutathione levels and thus reduce the tissue damage derived from intestinal oxidative stress which characterizes inflammatory colitis.

References (26)

  • B. Havsteen

    Biochem Pharmacol

    (1983)
  • A. Mora et al.

    Biochem Pharmacol

    (1990)
  • G.P. Morris et al.

    Gastroenterology

    (1989)
  • J.E. Krawisz et al.

    Gastroenterolgy

    (1984)
  • O.A. Bessey et al.

    J Biol Chem

    (1946)
  • M.M. Bradford

    Anal Biochem

    (1976)
  • M.E. Anderson

    Methods Enzymol

    (1985)
  • T. Yamada et al.

    Gastroenterology

    (1992)
  • H. Allgayer et al.

    Gastroenterolgy

    (1989)
  • G.T. Fantry et al.

    Curr Opin Gastroenterol

    (1993)
  • T. Yamada et al.
  • E. Middleton et al.
  • F.L.-H. Sanchez de Medina et al.

    J Pharm Exp Ther

    (1996)
  • Cited by (99)

    • Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

      2023, International Journal of Biological Macromolecules
    • Polyphenols in the Prevention of Ulcerative Colitis: A Revisit. A Revisit.

      2019, Dietary Interventions in Gastrointestinal Diseases: Foods, Nutrients, and Dietary Supplements
    • Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage

      2016, Pharmacological Reports
      Citation Excerpt :

      Isoquercitrin was tested at the daily doses of 1 and 10 mg/kg/day. These doses were selected on the basis of in vivo studies showing the anti-inflammatory activity of related flavonoids including quercetin [14] and quercetin glycosides, quercitrin (quercetin-3-O-α-l-rhamnopyranoside) [15,14] and rutin (quercetin-3-O-β-rutinoside) [16,17]. In our study, rats were daily administered isoquercitrin by oral gavage for 2 weeks, and during the last 7 days the intestinal inflammation was induced by oral administration of 5% DSS in drinking water.

    View all citing articles on Scopus
    View full text