Letters to the EditorSerotonin transporter gene polymorphism and affective disorder
References (3)
- et al.
Polymorphism in serotonin transporter gene associated with susceptibility to major depression
Lancet
(1996)
Cited by (92)
Imaging genetics studies on monoaminergic genes in major depressive disorder
2016, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :The l and s variants of the promoter polymorphism have been reported to have functional differences in modulating transcription of the 5-HTT gene as well as subsequent 5-HTT availability (Heils et al., 1996). Some reports describe an association between depression and the s/s genotype (Bellivier et al., 1998; Cervilla et al., 2006; Gutierrez et al., 1998; Kunugi et al., 1997; Ramasubbu et al., 2006), while other studies have failed to report such an association (Collier et al., 1996; Furlong et al., 1998; Stober et al., 1996). Previous imaging genetics studies have reported 5-HTTLPR exhibiting opposing effects on MDD patients and healthy controls (Frodl et al., 2008).
Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia
2014, Comprehensive PsychiatryCitation Excerpt :Contrary to the positive meta-analysis finding by Furlong et al. (1998) [12] and Jessica et al. (2004) [21], this study failed to detect the association between serotonin transporter gene and bipolar disorder pooled subjects and also after stratification into 3 major subethnic groups, the Malays, Chinese and Indians. Nonetheless, this finding is consistent with studies done in a group of 50 Indian bipolar patients when compared with 50 ethnically matched control [22] and in a sample of 137 Han Chinese patients compared with 362 ethnically matched control [23] or in several independent samples of Caucasians [24,25]. We found a captivating result that the 5-HTTLPR homozygous ss genotype and short allele were absent in both Chinese healthy control and bipolar proband group.
Genetic approaches for understanding the role of serotonin receptors in mood and behavior
2013, Current Opinion in NeurobiologyCitation Excerpt :With advances in various genetic technologies, we are now moving beyond variants that affect protein structure and function to investigate human regulatory variants that have been implicated in mood and behavior. This includes the well-known serotonin transporter polymorphism (5-HTTLPR) [27], and the 5-HT1A G(-1019)C regulatory polymorphism (rs6295), which has been associated with differences in 5-HT1A levels in the raphe, depression risk, and antidepressant responsiveness [23,28]. Mouse models of such polymorphisms will elucidate their specific temporal and regional effects on gene expression, revealing the impact of common genetic variation in shaping individual differences in behavior and disease susceptibility.
Fenfluramine disrupts the mitral valve interstitial cell response to serotonin
2009, American Journal of PathologyCitation Excerpt :Furthermore, 5HTT inhibitors, especially the selective 5HT reuptake inhibitors, such as fluoxetine, are widely used for treating depression, and their role over time concerning their potential effects on heart valve disease, either de novo or pre-existing, has been investigated to a very limited extent in a single cross-sectional study.38 In addition, a 5HTT polymorphism in the promoter region of human 5HTT has a Mendelian distribution in the general population.39,40 This 47 bp deletion has been associated with diminished 5HTT function.