Research reportLactate spares glucose as a metabolic fuel in neurons and astrocytes from primary culture
References (60)
- et al.
Function and regulation of the pentose phosphate pathway in brain
- et al.
Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
Brain Res.
(1972) Nutrients for the brain: problems in supply
Early Human Development
(1981)- et al.
Glycogen in astrocytes, possible function as lactate supply for neighboring cells
Brain Res.
(1993) - et al.
Uptake of l.-lactate by cultured rat brain neurons
Neurosci. Lett.
(1993) - et al.
Alternative pathways of glucose utilization in brain. Changes in the pattern of glucose utilization in brain during development and the effect of phenazine methosulphate on the integration of metabolic routes
Arch. Biochem. Biophys.
(1979) - et al.
The relationships between substrates and enzymes of glycolysis in brain
J. Biol. Chem.
(1964) - et al.
Protection by lactate of cerebral function during hypoglycaemia
Lancet
(1994) - et al.
Non-gluconeogenic fate of lactate during the early neonatal period in the rat
FEBS Lett.
(1980) - et al.
Role of fructose 2,6-bisphosphate in the regulation of glycolisis in various types of cultivated brain cell
Neurosci. Lett.
(1984)
First direct demonstration of preferential release of citrate from astrocytes using 〈C-13〉 NMR spectroscopy of cultured neurons and astrocytes
Neurosci. Lett.
d-glu-cose determination with hexokinase and glucose-6-phosphate dehydrogenase
Lactate and postischemic recovery of energy metabolism and electrical activity in the isolated perfused rat brain
J. Neurosurg. Anesthesiol.
Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. I. Neurons and glia
J. Electron Microsc. Tech.
Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes
J. Neurochem.
Glycolytic and TCA cycle enzymes
Prematurity in the rat. I. Fuels and gluconeogenic enzymes
Biol. Neonate
Preparation of antisera to neurofilament protein from chicken brain and human sciatic nerve
J. Comp. Neurol.
Lactate, 3-hydroxybutyrate and glucose as substrates for the early postnatal rat brain
Neurochem Res
Energy metabolism in developing brain cells
Can. J. Physiol. Pharmacol.
Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes and oligodendrocytes from developing brain in primary culture
J. Neurosc. Res.
Postnatal hypoglycxmia and gluconeogenesis in the newborn rat. Delayed onset of gluconeogenesis in prematurely delivered newborns
Biochem. J.
Fuels, hormones and liver metabolism at term during the early postnatal period in the rat
J. Clin. Invest.
l-(+)-Lactate determination with lactate dehydrogenase and NAD
Biosynthesis of phosphatidic acid in rat brain via acyldihydroxyacetone phosphate
J. Neurochem.
Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures
Neurochem. Res.
Energy metabolism at the cellular level of the CNS
Can. J. Physiol. Pharmacol.
Alternative pathways of glucose utilization in brain; changes in the pattern of glucose utilization in brain resulting from treatment of rats with 6-aminonicotinamide
J. Neurochem.
Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
Neuroreport
Attenuation of postnatal hypoxia in the premature newborn rat by maternal treatment with dexamethasone: its relationship with lung phospholipid content
Biol. Neonate
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2021, Free Radical Biology and MedicineCitation Excerpt :With the glucose SIL tracers revealing that glucose utilization and oxidation is not decreased in MB exposed neuroblastoma cells and Seahorse results showing eliminated glucose-associated acidification, these results may indicate a possible modification of lactate dynamics. Thus, we investigated lactate usage by increasing extracellular lactate during MB exposure, simulating nutrient support from astrocytes [28,29] (Fig. 8A). As we hypothesized, after 2 h metabolizing 13C3-labeled lactate, enriched TCA intermediates were increased after MB exposure (Fig. 8B–C), demonstrating that MB-exposed cells use lactate as an alternative fuel source under metabolic stress.
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2011, American Journal of Obstetrics and GynecologyCitation Excerpt :Indeed, 3 of the 5 IUGR fetuses with cerebral lactate in this study had a good short-term outcome; the pregnancies continued for some weeks after spectral acquisition. The detection of brain lactate in appropriately grown fetuses indicates that it may play a role in normal cerebral development; it has been purported to act as a fuel source in the immature brain.43,44 This study has some limitations.
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