Psychological stress selectively increases extracellular dopamine in the ‘shell’, but not in the ‘core’ of the rat nucleus accumbens: a novel dual-needle probe simultaneous microdialysis study
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Acknowledgements
This work was partly supported by the Grant-in-Aid for Scientific Research (#11670108) to M. Tanaka from the Ministry of Education, Science and Culture of Japan. We wish to thank Professor Gary B. Glavin of the Department of Pharmacology and Therapeutics, University of Manitoba, Canada, for his kind reviewing of an earlier version of this manuscript and helpful discussions.
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Social interaction reward decreases p38 activation in the nucleus accumbens shell of rats
2015, NeuropharmacologyCitation Excerpt :Indeed, mild footshock stress selectively increased extracellular dopamine levels in the shell while the levels of dopamine remained unaltered in the core of the nucleus accumbens (Kalivas and Duffy, 1995). Consistently, psychological stress for 20 min significantly increased extracellular dopamine levels in the shell but not the core of the nucleus accumbens (Wu et al., 1999). Moreover, short duration immobilization stress selectively increased dopamine utilization in the shell of the nucleus accumbens (Deutch and Cameron, 1992).
The mesoaccumbens dopamine in coping with stress
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :These considerations suggest that activation of mesoaccumbens DA release in stressful conditions may be associated with activation of defense against threatening stimuli. In stressed animals, DA releases has been reported to increase in the shell but not the core compartment of the NAc (Kalivas and Duffy, 1995; Wu et al., 1999; Barrot et al., 2000), a selectivity that may depend on glucocorticoids (Barrot et al., 2000; Marinelli and Piazza, 2002). Moreover, expression of active coping responses seems to depend on stimulation of D2 receptors within the NAc shell (Scornaiencki et al., 2009).
Cocaine during adolescence enhances dopamine in response to a natural reinforcer
2007, Neurotoxicology and Teratology