Repeats in genomic DNA: mining and meaning

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Abstract

For hundreds of millions of years, perhaps from the very beginning of their evolutionary history, eukaryotic cells have been habitats and junkyards for countless generations of transposable elements, preserved in repetitive DNA sequences. Analysis of these sequences, combined with experimental research, reveals a history of complex ‘intracellular ecosystems’ of transposable elements that are inseparably associated with genomic evolution.

References (46)

  • P Capy

    Classification of transposable elements

  • J Brosius et al.

    Reverse transcriptase: mediator of genomic plasticity

    Virus Genes

    (1996)
  • MG Kidwell et al.

    Transposable elements as sources of variation in animals and plants

    Proc Natl Acad Sci USA

    (1997)
  • NV Tomilin

    Control of genes by mammalian retroposons

    Int Rev Cytol

    (1998)
  • WM Chu et al.

    Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR

    Mol Cell Biol

    (1998)
  • FJ Gueiros-Filho et al.

    Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania

    Science

    (1997)
  • Repbase Update

    (1997)
  • Genetic Information Research Institute on the World Wide Web URL:...
  • AFA Smit

    The origin of interspersed repeats in the human genome

    Curr Opin Genet Dev

    (1996)
  • C Burge et al.

    Prediction of complete gene structures in human genomic DNA

    J Mol Biol

    (1997)
  • JM Claverie

    Computational methods for the identification of genes in vertebrate genomic sequences

    Hum Mol Genet

    (1997)
  • M Shimamura et al.

    Molecular evidence from retroposons that whales form a clade within even-toed ungulates

    Nature

    (1997)
  • D Halverson et al.

    A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B

    J Cell Biol

    (1997)
  • Cited by (0)

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