Immunity
Volume 10, Issue 5, 1 May 1999, Pages 607-617
Journal home page for Immunity

Article
Increased Junctional Diversity in Fetal B Cells Results in a Loss of Protective Anti-Phosphorylcholine Antibodies in Adult Mice

https://doi.org/10.1016/S1074-7613(00)80060-6Get rights and content
Under an Elsevier user license
open archive

Abstract

Fetal Igs are less diverse than adult Igs, largely because of the lack of N addition in the absence of Tdt. To test whether the absence of Tdt is essential, we generated Tg mice that express Tdt and add N regions in fetal B cells. When challenged as adults with PC-containing Streptococcus pneumoniae, these mice fail to make the hallmark T15 anti-PC Ab encoded by canonical rearrangements of Ig H and L chain genes. The anti-PC Abs from these mice are altered by premature N addition and do not protect against death from virulent pneumococcal infection. These results show that maintenance of lower Ig diversity in early life is essential for the acquisition of a complete functional adult repertoire.

Cited by (0)