Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 11, November 2011, Pages 1498-1507
ReviewPP2A targeting by viral proteins: A widespread biological strategy from DNA/RNA tumor viruses to HIV-1
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Highlights
► The family of PP2A holoenzymes are specific targets for multiple viruses. ► Viruses use PP2A to specifically subvert key survival pathways of their hosts. ► Proteins encoded by DNA/RNA tumor viruses bind PP2A to activate oncogenic pathways. ► PP2A dysfunction is associated to cancer and neurodegeneration. ► The study of PP2A dysfunction is a powerful approach for human therapy.
Keywords
Viruses
Cancer
Neurodegeneration
PP2A holoenzymes
PP2A and human therapy
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