Biochemical and Biophysical Research Communications
Breakthroughs and ViewsCoordinated interaction of the vascular and nervous systems: from molecule- to cell-based approaches
Section snippets
Coordinated regulation of neuroangiogenic factors generated from blood vessels and nerves
In the developing embryo and adult, endothelial cells (ECs) and neuronal cells respond to changing environments through the production of growth factors and their receptors. The factors/receptors act as sensors of such environmental changes and transduce information into the inside of cells and finally induce proliferation, migration, and differentiation of ECs and neuronal cells. Thus, a great deal of research in angiogenesis and neurogenesis has been focused on neuroangiogenic factors and
Neurovascular coordination during angiogenesis and neurogenesis
In the adult brain, neurogenic activity usually persists in neuroproliferative regions, including the subgranular zone of hippocampal dentate gyrus (SGZ), ventricle zone (VZ), and olfactory bulb [29]. The neuroproliferative regions include precursors of neurons, glia, and ECs, which secrete neuroangiogenic factors and form neuroangiogenic niches for instructive signals [29]. Following brain injuries such as brain ischemia and degenerative neuronal diseases, the recovery of the damaged neurons
Perspectives: in resonance with the vascular and nervous systems
Much of the current research has been attempted to understand the molecular and intercellular events that coordinate blood vessels and nerves in the pathophysiological system. Blood vessels and nerves construct highly organized networks, respond appropriately to the local demand, and then execute brain functions through coordinated processes (Fig. 1). However, disruption of their resonance might lead to pathological states, such as brain ischemia, vascular dementia, aging brain, amyotrophic
Acknowledgements
This work was supported by the National Research Laboratory Fund (2000-N-NL-01-C-015) from the Ministry of Science and Technology, Korea (to K.-W. K.), and the Vascular System Research Center grant from the Korea Science and Engineering Foundation, Korea.
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