Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells

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Abstract

Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.

Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.

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Acknowledgements

This work was supported by the Korea Research Foundation Grants (KRF-2002-003-E00194 and 2002-042-E00109).

References (30)

  • A Eckert et al.

    Biochem. Pharmacol.

    (2003)
  • G.R Beecher

    J. Nutr.

    (2003)
  • C.N Wang et al.

    J. Biol. Chem.

    (2001)
  • S.C Shen et al.

    Eur. J. Pharmacol.

    (2002)
  • K Blomgren et al.

    J. Biol. Chem.

    (2001)
  • C Widmann et al.

    J. Biol. Chem.

    (1998)
  • E Adamec et al.

    Brain Res. Brain Res. Protoc.

    (2001)
  • P Li et al.

    Cell

    (1997)
  • Z Gao et al.

    Biochim. Biophys. Acta

    (1999)
  • J.L Martindale et al.

    J. Cell Physiol.

    (2002)
  • J.A Klein et al.

    J. Clin. Invest.

    (2003)
  • P Jenner

    Ann. Neurol.

    (2003)
  • P Lipton

    Physiol. Rev.

    (1999)
  • J.A Ross et al.

    Ann. Rev. Nutr.

    (2002)
  • H Lee et al.

    FASEB J.

    (2003)
  • Cited by (0)

    View full text