Regulation of ATP production by mitochondrial Ca2+
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Abbreviations
[ATP/ADP]c
cytosolic ATP/ADP ratio
[Ca2+]c, [Ca2+]m
cytosolic and mitochondrial free concentrations of calcium
EC
excitation-contraction
ICEU
intracellular energy unit
KATP
ATP-sensitive K+ channel
MCU
mitochondrial uniporter
mNCX/NCLX
mitochondrial sodium-calcium exchanger
Pi, PPi
inorganic phosphate and pyrophosphate, respectively
RuR
ruthenium red
Keywords
ATP
Mitochondria
Calcium
Heart
Beta cell
Islet
Insulin
Secretion
Diabetes
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These authors contributed equally.
Copyright © 2012 Elsevier Ltd.