Cell
Volume 142, Issue 2, 23 July 2010, Pages 196-198
Journal home page for Cell

Preview
SRD5A3: A Surprising Role in Glycosylation

https://doi.org/10.1016/j.cell.2010.07.003Get rights and content
Under an Elsevier user license
open archive

The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

Cited by (0)