Cell
Volume 142, Issue 6, 17 September 2010, Pages 967-980
ResourceQuantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
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Graphical Abstract
Highlights
► MS-based proteomics screen identifies novel histone lysine trimethylation readers ► Readers are assembled into complexes and their genome-wide occupancy is determined ► Sgf29 links the SAGA complex to H3K4me3 via a double tudor domain ► Trimethyl reader complexes determine the biological function of their epigenetic mark
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These authors contributed equally to this work
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Present address: Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
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