Cell
Volume 147, Issue 4, 11 November 2011, Pages 840-852
ArticleA Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans
Under an Elsevier user license
open archive
Graphical Abstract
Highlights
► SREBP-1 transcription factors regulate the one-carbon cycle in metazoans ► Low levels of SAMe and phosphatidylcholine (PC) activate SREBP-1 and lipogenesis ► Low PC production causes Golgi to ER relocalization of SREBP-activating proteases ► PC depletion preferentially affects SREBP-1, whereas cholesterol regulates SREBP-2
Cited by (0)
- 7
Present address: Albert Einstein College of Medicine, 1301 Morris Park Avenue, Room 368, Bronx, NY 10461, USA
- 8
Present address: Department of Neuroscience, Brown University, 185 Meeting Street, SFH458 Mailbox GL-N, Providence, RI 02912, USA
Copyright © 2011 Elsevier Inc. All rights reserved.