Cell
Volume 151, Issue 4, 9 November 2012, Pages 847-858
ArticleThe Spinocerebellar Ataxia-Associated Gene Tau Tubulin Kinase 2 Controls the Initiation of Ciliogenesis
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Graphical Abstract
Highlights
► Tau tubulin kinase 2 (Ttbk2) is essential for mouse Shh signaling and ciliogenesis ► TTBK2 recruits IFT proteins and removes CP110 from the mother centriole ► TTBK2 recruitment to the basal body correlates with the removal of CP110 ► Human TTBK2 mutations that cause SCA11 inhibit cilia formation in wild-type cells
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Present address: Vertebrate Developmental Biology Program, Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA
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