Cell Reports
Volume 2, Issue 1, 26 July 2012, Pages 136-149
ArticleAge-Related Oxidative Stress Compromises Endosomal Proteostasis
Under a Creative Commons license
open access
Graphical Abstract
Highlights
► Aging dendritic cells (DCs) are characterized by an oxidatively modified proteome ► Aggregates of oxidized proteins accumulate in endosomal compartments ► The oxidatively damaged proteome compromises DC antigen processing and presentation ► Antioxidant treatment partially restores DCs' priming ability only in aging mice
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Present address: Department of Medical Sciences, University of Piemonte Orientale Medical School, Novara 28010, Italy
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Present address: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
Copyright © 2012 The Authors. Published by Elsevier Inc.