Cell Reports
Volume 22, Issue 1, 2 January 2018, Pages 175-188
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Article
The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

https://doi.org/10.1016/j.celrep.2017.12.029Get rights and content
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Highlights

  • Apolipoprotein M (apoM) deficiency increases the amount of brown adipose tissue

  • ApoM deficiency accelerates postprandial triglycerides

  • ApoM deficiency protects against diet-induced obesity and improves glucose tolerance

  • Decreased sphingosine-1-phosphate stimulation increases brown adipose tissue weight

Summary

Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1–5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

Keywords

apolipoproteins
sphingolipids
sphingosine-1-phosphate
lipoproteins
lipid metabolism
triglyceride
brown adipose tissue
apoM

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Present address: Aarhus University, Aarhus, Denmark

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