Current Biology
Volume 30, Issue 6, 23 March 2020, Pages 1152-1159.e3
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Single Neuron Coding of Identity in the Human Hippocampal Formation

https://doi.org/10.1016/j.cub.2020.01.035Get rights and content
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Highlights

  • Most human MTL neurons show a nearly binary coding of identity

  • Pictures of the same person could not be distinguished from the neural responses

  • The MTL binary coding contrasts with the graded coding typically seen in neocortex

  • Binary coding offers advantages for the encoding and retrieval of episodic memories

Summary

Experimental findings show the ubiquitous presence of graded responses and tuning curves in the neocortex, particularly in visual areas [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. Among these, inferotemporal-cortex (IT) neurons respond to complex visual stimuli, but differences in the neurons’ responses can be used to distinguish the stimuli eliciting the responses [8, 9, 16, 17, 18]. The IT projects directly to the medial temporal lobe (MTL) [19], where neurons respond selectively to different pictures of specific persons and even to their written and spoken names [20, 21, 22]. However, it is not clear whether this is done through a graded coding, as in the neocortex, or a truly invariant code, in which the response-eliciting stimuli cannot be distinguished from each other. To address this issue, we recorded single neurons during the repeated presentation of different stimuli (pictures and written and spoken names) corresponding to the same persons. Using statistical tests and a decoding approach, we found that only in a minority of cases can the different pictures of a given person be distinguished from the neurons’ responses and that in a larger proportion of cases, the responses to the pictures were different to the ones to the written and spoken names. We argue that MTL neurons tend to lack a representation of sensory features (particularly within a sensory modality), which can be advantageous for the memory function attributed to this area [23, 24, 25], and that a full representation of memories is given by a combination of mostly invariant coding in the MTL with a representation of sensory features in the neocortex.

Keywords

single neurons
hippocampus
medial temporal lobe
memory
invariance

Cited by (0)

5

These authors contributed equally

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Present address: Department of Psychology, University of Oslo, Postboks 1094 Blindern, Oslo 0317, Norway

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Lead Contact