Developmental Cell
Volume 23, Issue 5, 13 November 2012, Pages 995-1005
ArticleSingle-Cell-Resolution Imaging of the Impact of Notch Signaling and Mitosis on Segmentation Clock Dynamics
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Graphical Abstract
Highlights
► Segmentation clock dynamics are imaged with cellular level of resolution ► Presomitic mesoderm cells oscillate asynchronously in the absence of Notch signaling ► After mitosis, sibling cells resume oscillations in tight synchrony with each other ► Mitosis occurs preferentially at the trough of the oscillation phase
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Present address: Laboratoire de Biologie Moléculaire de la Cellule, UMR 5239 CNRS-UCBL-ENS Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France
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Present address: Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
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These authors contributed equally to this work
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