ReviewBiomarkers of aging and disease: Introduction and definitions
Section snippets
NIA biomarkers of aging program
In 1988 the National Institute on Aging began a 10 year initiative to develop biomarkers of aging (Sprott and Austad, 2006). Over the 10 year period this initiative funded 18 laboratories to conduct the search for biomarkers of aging in an array of physiological and behavioral systems. All of the animals (mice) used in these studies were raised in a single facility, fed the same diets (ad lib or calorically restricted) and then sent to the investigators laboratories in order to eliminate the
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Recent advances in electrochemical biosensors for the detection of Aβ42, a biomarker for Alzheimer disease diagnosis
2023, TrAC - Trends in Analytical ChemistryLife course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study
2022, The Lancet Healthy LongevityCitation Excerpt :A reliable cross-sectional metric that can quantify this variability—a measure of biological age—would be valuable both for clinical practice and research into longevity and ageing health. This metric could facilitate the monitoring of age-related changes beyond that captured by disease specific risk factors—ie, by incorporating mechanisms of decline due to both disease and typical ageing.1 Likewise, the metric could help to detect people who are ageing more rapidly than expected, before the onset of clinical manifestations,2 alongside being able to detect traits related to delayed ageing, cognitive maintenance, and longevity.
Longevity as a complex genetic trait
2021, Handbook of the Biology of Aging