DermatopathologyHuman polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses
Section snippets
Methods
This was a retrospective case series of archived skin biopsy specimens. Histologically normal-appearing skin and archived biopsy samples were obtained through an institutional review board–exempt protocol. For patient B, written, informed consent was obtained for collecting skin swabs for diagnostic and research purposes.
Results
The clinical characteristics of the patients, which have been previously reported, are summarized in Table I.12, 13 All 3 patients presented with generalized, scaly, hyperpigmented papules coalescing into plaques, which were all present for at least 12 months. All dermatoses were associated with some degree of pruritus (Fig 1, A, and Table I). Although patient A was immunosuppressed from HIV that had progressed to AIDS, patient C was immunosuppressed from a kidney/pancreas transplant.
Discussion
Ho et al9 first associated HPyV7 infection with pruritic rashes in immunosuppressed transplant recipients with a characteristic peacock plumage histology. Our study confirms and extends these seminal findings by linking HPyV6 with similar rashes. This study also broadens the range of immunosuppressed states that may allow for HPyV7 infection from iatrogenic immunosuppression from organ transplantation to the immunocompromised state of HIV infection. Of note, the patient with HIV described here
References (21)
- et al.
New human papovavirus (B.K.) isolated from urine after renal transplantation
Lancet
(1971) - et al.
Cultivation of papova-like virus from human brain with progressive multifocal leukoencephalopathy
Lancet
(1971) - et al.
Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
Cell Host Microbe
(2010) - et al.
Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing
Virology
(2013) - et al.
A cornucopia of human polyomaviruses
Nat Rev Microbiol
(2013) - et al.
Clonal integration of a polyomavirus in human Merkel cell carcinoma
Science
(2008) - et al.
Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromised patient
PLoS Pathog
(2010) - et al.
Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus
J Cutan Pathol
(2011) - et al.
Human polyomaviruses 6, 7, 9, 10 and trichodysplasia spinulosa-associated polyomavirus in HIV-infected men
J Gen Virol
(2014) - et al.
Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients
J Infect Dis
(2015)
Cited by (64)
Quantification of human polyomaviruses MCPyV and HPyV6 in malignant and non-malignant skin lesions
2023, Anais Brasileiros de DermatologiaJC and Human polyomavirus 9 after kidney transplantation: An exploratory serological cohort study
2021, Journal of Clinical VirologyHost-Pathogen Interactions in Human Polyomavirus 7‒Associated Pruritic Skin Eruption
2021, Journal of Investigative DermatologyKeratotic spines in a patient with pruritic and dyskeratotic dermatosis: A new clinical finding
2021, JAAD Case ReportsCitation Excerpt :Cutaneous manifestations associated with the Polyomaviridae include Merkel cell carcinoma, trichodysplasia spinulosa (TS), and, more recently, pruritic and dyskeratotic dermatosis (PDD). The viruses responsible for disease are Merkel cell polyomavirus, TS-associated polyomavirus, human polyomavirus 6 (HPyV6), and human polyomavirus 7 (HPyV7).1-3 We report a patient with an unusual presentation of PDD that included a lichenified dermatosis associated with alopecia and follicularly-based keratotic papules.
Human Polyomavirus 6 with the Asian–Japanese Genotype in Cases of Kimura Disease and Angiolymphoid Hyperplasia with Eosinophilia
2020, Journal of Investigative Dermatology
Supported by the National Institutes of Health (National Cancer Institute Intramural Research Program to Dr Buck and K08 CA164047 to Dr Wang), a Burroughs Wellcome Fund Career Award for Medical Scientists (1010978) to Dr Wang, and a Disease-Oriented Clinical Scholar Awards to Dr Wang.
Conflicts of interest: None declared.
Reprints not available from the authors.