Original ResearchHuman Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion
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Author contributions Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, Catherine Tomaro-Duchesneau, Umesh C. Karandikar, Mary K. Estes, Robert A. Britton, and Joseph M. Hyser were responsible for the concept and design; Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, Catherine Tomaro-Duchesneau, Umesh C. Karandikar, Mary K. Estes, James Versalovic, Robert A. Britton, and Joseph M. Hyser provided intellectual contributions; Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, Catherine Tomaro-Duchesneau, and Umesh C. Karandikar acquired data; Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, Catherine Tomaro-Duchesneau, and Umesh C. Karandikar performed the data analysis, statistical analysis, and interpretation; Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, and Joseph M. Hyser drafted and edited the manuscript; and Mary K. Estes, James Versalovic, Robert A. Britton, and Joseph M. Hyser obtained funding.
Conflicts of interest The authors disclose no conflicts.
Funding Supported by National Institutes of Health grants F30 DK112563 (A.C.G), U01 CA170930 (J.V.), R01 DK103759 (R.A.B), U19 AI116497, R01 AI080656 (M.K.E.), R03 DK110270, and R01 DK115507 (J.M.H.); Baylor College of Medicine Seed Funding (J.M.H.); and Fonds de Recherche Santé Québec (C.T.D.). This project also was supported in part by the National Institutes of Health Public Health Service (PHS) grant P30 DK056338 for the Texas Medical Center Digestive Diseases Center. Additional funding support for the Baylor College of Medicine Integrated Microscopy Core was provided by the National Institutes of Health (DK56338, CA125123), Cancer Prevention and Research Institute of Texas (RP150578, RP170719), the Dan L. Duncan Comprehensive Cancer Center, and the John S. Dunn Gulf Coast Consortium for Chemical Genomics.
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Authors share co-first authorship.