Letter to the EditorDetection of mobile colistin resistance gene mcr-9 in carbapenem-resistant Klebsiella pneumoniae strains of human origin in Europe
Section snippets
Author contributions
G.F.G. designed the study. Y.N.W. and F.L. collected and downloaded the datasets. Y.N.W., F.L., Y.F.H., B.L.Z., G.P.Z., and G.F.G. analyzed and interpreted the data. Y.N.W. and G.F.G. wrote the draft of the manuscript. All authors discussed, reviewed and approved the final report.
Supplementary Tables
Supplementary information is available for this paper. Correspondence and requests for materials should be addressed to G.F.G.
Declaration of Competing Interest
The authors declare no competing interests.
Acknowledgements
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB29010000), the External Cooperation Program of CAS (153211KYSB20160001), and National Key R&D Program of China (2018YFC1603803).
References (16)
- et al.
Antibiotic resistance gene reservoir in live poultry markets
J Infect
(2019) - et al.
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
Lancet Infect Dis
(2018) - et al.
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study
Lancet Infect Dis
(2016) - et al.
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae
J Antimicrob Chemothery
(2018) - et al.
Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae
Emerg Microbes Infect
(2018) - et al.
Metagenomic data screening reveals the distribution of mobilized resistance genes tet(X), mcr and carbapenemase in animals and humans
J Infect
(2019) - et al.
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
Nat Microbiol
(2019) - et al.
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans
Nat Microbiol
(2019)
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Hidden threats in the plastisphere: Carbapenemase-producing Enterobacterales colonizing microplastics in river water
2024, Science of the Total EnvironmentCarriage of the mcr-9 and mcr-10 genes in clinical strains of the Enterobacter cloacae complex in China: a prevalence and molecular epidemiology study
2022, International Journal of Antimicrobial AgentsCitation Excerpt :Intriguingly, mcr-9 exhibits an unexpectedly high prevalence rate in ECC (10.7%), which is even higher than that of mcr-1 (< 1%) detected in ECC [28]. Similarly, the prevalence of mcr-9 in CRECC (31.8%) was also much higher than that of other carbapenem-resistant species [29,30]. These results indicate that ECC may be an important reservoir of mcr-9.
Novel Quadruplex PCR for detecting and genotyping mobile colistin resistance genes in human samples
2021, Diagnostic Microbiology and Infectious DiseaseCitation Excerpt :Since the first report of mcr-1 from animal origin (Liu et al., 2016), mobile colistin-resistance (mcr) genes have been found in many animal and environmental samples. Many researches indicated that, the transmission of mcr-1 and mcr-3 were largely associated with the dissemination from the environment or animalistic food to human rather than the tradition concerning pathway that is, from the human to the environment (AbuOun et al., 2017; Borowiak et al., 2017; Wang et al., 2020; Carattoli et al., 2017; Kieffer et al., 2019; Shen et al., 2018; Wang et al., 2017; Wang et al., 2020; Wang et al., 2019; Xavier et al., 2016; Yang et al., 2018; Yin et al., 2017). Specifically, the carriage of mcr-1 in health individuals was much more associated with the living next to a farm, the production of sheep and freshwater aquaculture, annual consumption of total meat, pork and mutton, and daily intake of aquaculture products (Shen et al., 2018; Wang et al., 2017).
Distribution of mcr genes among carbapenem-resistant Enterobacterales clinical isolates: high prevalence of mcr-positive Enterobacter cloacae complex in Seoul, Republic of Korea
2021, International Journal of Antimicrobial AgentsCitation Excerpt :For instance, in China, 0.75% of CRE strains collected from humans have been reported to carry mcr-1 [5]. In Europe, mcr-9 was identified in 1.63% of carbapenem-resistant K. pneumoniae strains [22]. To the best of the authors’ knowledge, this is the first study to report the prevalence of mcr genes in CRE strains from Seoul, Korea.
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These authors contributed equally to this work.