Journal of Molecular Biology
CommunicationThe Solution Structure of Antigen MPT64 from Mycobacterium tuberculosis Defines a New Family of Beta-Grasp Proteins
Section snippets
Rv1980c adopts a novel fold containing a β-grasp motif
To provide unique and complementary insights into the potential functions of this protein family, we used heteronuclear NMR techniques to determine the solution structure of Rv1980c. A representation of the average Rv1980c structure along with overlaid stereo images of the 24 lowest energy backbone traces of Rv1980c are shown in Figure 1(a) and (b), respectively. In addition, structural statistics are summarized in Table 1. Details of NMR data collection and protein backbone and side-chain
Protein Data Bank accession codes
The coordinates for Rv1980c have been deposited under accession code 2HHI.
Acknowledgements
We thank Kasra Ramyar for helpful comments on the manuscript. This research was funded by grant AI69001 from the National Institute for Allergy and Infectious Diseases (to B.V.G. and J.H.L.).
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Z.W. and B.M.P. contributed equally to this work.