Journal of Molecular Biology
Volume 366, Issue 1, 9 February 2007, Pages 1-13
ReviewtRNA’s Wobble Decoding of the Genome: 40 Years of Modification
Section snippets
Discussion
The longest measured distance across the anticodon-codon minihelix on the ribosome is that found for the purine–purine interaction of the I34•A3 base-pair, 12.3 Å.74 Interestingly, the phosphate–phosphate distance across the helix changes little for wobble base-pairs.74 One can conclude that the ribosome is tolerant of the wider wobble base-pair geometries of modified U34•A3, or G3 and I34•A3, but not the narrower 8.5 Å diameter of pyrimidine-pyrimidine base-pairs found in RNA structures. The
Acknowledgements
This work was supported by grants from the National Institutes of Health (2-RO1-GM23037) and the National Science Foundation (MCB-0548602) to P.F.A.
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