Journal of Molecular Biology
Volume 425, Issue 9, 13 May 2013, Pages 1424-1432
Cooperativity of Allosteric Receptors
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open access
Graphical Abstract
Highlights
► The nH values for conformational transitions require a reference state. ► For conformational transitions with nH > 1, for the equivalent monomer: nH < 1. ► The true ratio of oligomer to monomer nH values is equal to the number of monomers. ► Normalization stretches the dose–response curve and increases the value of nH. ► The equivalent monomer concept was first proposed in 1965 by Crick and Wyman.
Abbreviations
GPCR
G-protein-coupled receptor
MWC
Monod–Wyman–Changeux
Keywords
pentameric ligand-gated channels
GPCRs
Hill coefficients
equivalent monomers
allosteric range
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