Language lateralization development in children with autism: Insights from the late field magnetoencephalogram

doi:10.1016/j.neulet.2005.05.037

Neuroscience Letters

Volume 386, Issue 2, 30 September 2005, Pages 82-87

https://doi.org/10.1016/j.neulet.2005.05.037 Get rights and content

Abstract

Left hemisphere dominance represents the typical language lateralization profile for the majority of neurologically healthy, right-handed individuals. We investigated hemispheric dominance for language in language-impaired children with autism and typically developing controls to investigate the hypothesis that atypical functional specialization for language represents one component of developmental language impairment in autism. Late field magnetoencephalography (MEG) recordings were used to calculate a hemispheric Lateralization Index from the neuromagnetic activity evoked by passive auditory presentation of vowel stimuli. Results indicate that children with autism and typically developing children follow opposite maturational trajectories in language lateralization; while leftward lateralization (i.e. left hemisphere dominance) emerged from bilaterally symmetric neuronal activation as age increased in our sample of typically developing children, rightward lateralization emerged from bilaterally symmetric activity as age increased in our sample of children with autism.

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Acknowledgments

We gratefully acknowledge grant support from NAAR, the CRC program (TPLR) and CIHR (JOC/TPLR).

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View full text

Language lateralization development in children with autism: Insights from the late field magnetoencephalogram

Abstract

Section snippets

Acknowledgments

Epilepsy Behav.

Dev. Brain Res.

Trends Cogn. Sci.

Cognition

NeuroImage

NeuroImage

NeuroImage

Neuropsychologia

Neurosci. Lett.

Brain Cogn.

A functional magnetic resonance imaging study of left hemisphere language dominance in children

Arch. Neurol.

Abnormal activation of temporoparietal language areas during phonetic analysis in children with dyslexia

Neuropsychology

Language dominance in children as determined by magnetic source imaging and the intracarotid amobarbital procedure: a comparison

J. Child Neurol.

Lateralization of activity associated with langauge function using magnetoencepholography—a reliability study

J. Clin. Neurophys.

Language dominance determined by magnetic source imaging—a comparison with the Wada procedure

Neurology

Linguistics and brain science

Evidence of brain overgrowth in the first year of life in children with autism

J. Am. Med. Assoc.

Language-association cortex asymmetry in autism and specific language impairment

Ann. Neurol.

Left-hemisphere dominance for processing of vowels: a whole-scalp neuromagnetic study

NeuroReport