A rapid fMRI task battery for mapping of visual, motor, cognitive, and emotional function
Introduction
Many studies have demonstrated that functional magnetic resonance imaging (fMRI) can reliably activate specific sensory, cognitive, and limbic systems within the human brain (Moonen and Bandettini, 1999, Cabeza and Nyberg, 2000, Cabeza and Kingstone, 2001, Sabatinelli et al., 2005). Most fMRI studies concentrate on one specific functional system and devote entire scanning sessions to probing its behavior. There are, however, numerous circumstances in which it would be advantageous to collect data from multiple systems within the brain of a single subject. While the time and expense associated with repeated fMRI sessions often discourages such studies, the development of a rapid and reliable task battery that targets multiple systems and can be performed in one study session could be put to use in a wide range of functional imaging applications. These include, for example, the localization of “eloquent” speech areas for neurosurgical planning, the establishment of functional activation markers for use in probing more complex regional functions, use as a benchmark dataset for testing in new imaging laboratories, and deployment as an educational tool for fMRI training. Accordingly, the principle goal of the present work is to demonstrate the viability of acquiring stable and reliable data from multiple brain systems with minimal commitment of scanner time. In the present study, we developed a battery of tasks that provides markers of activity in multiple brain systems (i.e., sensory, motor, cognitive, and limbic) in individual subjects within a relatively short acquisition time of 2.5 min per task or approximately 12.5 min for one run of the full functional battery (apart from the anatomical acquisition).
In clinical practice, several paradigms are used to identify the sensory and motor areas (Lee et al., 1998, Bittar et al., 1999, Boling et al., 1999) and language-related areas (Binder et al., 1997, FitzGerald et al., 1997, Benson et al., 1999, Fernandez et al., 2001). Some batteries have been developed for neurosurgical planning that include multiple, overlapping tasks for motor and language mapping (Tomczak et al., 2000, Heilbrun et al., 2001, Haberg et al., 2004), and one battery includes tasks for motor, sensory, and language mapping (Hirsch et al., 2000). These batteries target regions considered most critical for surgical decisions and are designed for patients with a wide range of symptoms and abilities. Consequently, the clinical batteries are designed to be simple to perform, so that the largest number of potentially impaired patients might comply with task directions, and they are geared to be most sensitive in visual, motor, and language areas that surgeons wish to spare to avoid devastating handicaps to patients. Such batteries consequently tend to ignore mapping of limbic and non-language cognitive functions.
The goals of this study were to develop a suite of common behavioral tasks, targeting sensory–motor areas as well as more complex cognitive and emotional functions, and that (a) can reliably localize the visual, motor, language, working memory, and limbic systems in individual subjects; (b) requires minimal data acquisition time to produce statistically reliable activity within predicted brain areas; (c) can be reproduced in any imaging center with standard functional imaging capabilities and basic analysis tools; and (d) can be used to produce functional localizers to support cross-laboratory comparisons. While the majority of data reported from fMRI tests are obtained on a relatively young cross-section of the population, mostly college students in their twenties, the present battery was tested on a cohort of subjects with a wider range of ages and educational and cultural backgrounds, thereby providing for an examination of age-based differences and allowing the results to be generalized to a broader population base. Other factors – such as head motion, task performance, and subject compliance – were evaluated to assess their impact on the ability of the task battery to accurately localize brain activity.
Section snippets
Subjects
Thirty-one, normal, healthy adults from age 22 to 76 (mean age 41 ± 15.3) were recruited for the study. All subjects were right-handed and fluent in English, with 25 native English speakers. Approximately an equal number of subjects were recruited to form three age groups: those age 30 or less, those 31 to 50 years old, and those older than 50. The youngest group of subjects was composed primarily of undergraduate and graduate students, thus providing a basis of comparison with the most common
Subject compliance, head movement, and task performance
Data regarding subject compliance, head movement, and performance are summarized in Table 1. The a priori inclusion criteria required performance with greater than 70% accuracy on each task and overall head motion of less than 1 voxel in size in any direction. All subjects, even those in the oldest group, were able to adequately hold their heads still and perform the tasks in the battery, so all subjects contributed data to the analyses. However, one run from a subject in the youngest group and
Discussion
A set of “classical” sensory–motor, cognitive, and emotional tasks was combined in a task battery and tested on a group of normal, healthy subjects across a wide range of ages in an effort to design a set of tasks that can be administered quickly to obtain prototyping data for fMRI studies. The functional portion of the battery can be administered in approximately 20–25 min, and with additional modifications, the battery might be even shorter. All of the tasks were successful in activating at
Acknowledgment
This study was supported by SBIR grant R44 MH058504-03 from the NIMH.
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