Therapeutic potential of resveratrol against emerging respiratory viral infections

https://doi.org/10.1016/j.pharmthera.2020.107613Get rights and content
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Abstract

Resveratrol has been widely studied for its therapeutic potential due to its antioxidant, anti-inflammatory and anti-microbial properties. In particular, resveratrol has shown promising antiviral activity against numerous viruses responsible for severe respiratory infections. Amongst these, influenza virus, respiratory syncytial virus and the emerging SARS-cov-2 are known to cause pneumonia, acute respiratory distress syndrome or multi-organ failure, especially, in vulnerable individuals like immunocompromised patients or the elderly, leading to a considerable economic burden worldwide. In this context, resveratrol may have potential value for its anti-inflammatory activity, since most of the severe virus-associated complications are related to the overactivation of the host-immune response, leading to lung damage.

Herein, we present an overview of the antiviral activity and potential mechanisms of resveratrol against the respiratory tract viruses considered as a public threat for their rapid transmission and high morbidity and mortality in the general population.

Keywords

Resveratrol
Emerging respiratory viruses
Anti-viral mechanisms

Abbreviations

ACE-2
angiotensin-converting enzyme-2
AHR
airway hyperresponsiveness
ARDS
acute respiratory distress syndrome
GSH
glutathione
HCoV
human coronavirus
hMPV
human metapneumovirus
HRV
human rhinovirus
ICAM-1
intercellular adhesion molecule-1
ICU
intensive care unit
IFN
interferon
IL
interleukin
IRF
interferon regulatory factor
MAPK
p38 mitogen-activated protein kinase
MERS-Cov
middle-east respiratory syndrome coronavirus
MIC
minimal inhibitory concentration
myD88
myeloid differentiation primary response 88
NF-κB
nuclear factor-κB
NK
natural killer
PKC
protein kinase C
RANTES
regulated on Activation Normal T Cell Expressed and Secreted
RNP
ribonucleoprotein
ROS
reactive oxygen species
RSV
respiratory syncytial virus
SARM
Sterile α and HEAT/Armadillo motif–containing protein
SARS-Cov
severe acute respiratory syndrome coronavirus
TBK1
TANK-binding kinase 1
TLR
toll-like receptor
TNFα
tumor necrosis factor-α
TRIF
TIR-domain-containing adapter inducing interferon-β

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