Elsevier

Research in Microbiology

Volume 160, Issue 9, November 2009, Pages 645-651
Research in Microbiology

Regulation and quality control by Lon-dependent proteolysis

https://doi.org/10.1016/j.resmic.2009.08.021Get rights and content
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Abstract

After their first discovery in Escherichia coli, Lon homologues were found to be widely distributed among prokaryotes to eukaryotes. The ATP-dependent Lon protease belongs to the AAA+ (ATPases associated with a variety of cellular activities) superfamily, and is involved in both general quality control by degrading abnormal proteins and in the specific control of several regulatory proteins. As such, this enzyme has a pivotal role in quality control and cellular physiology. This review focuses on mechanisms of degradation both from the protease and substrate points of view, and discusses the role of Lon in global regulation, stress response and virulence.

Keywords

Lon protease
Gene expression regulation
Stress response

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